Tesamorelin (brand name EGRIFTA) is a synthetic hormone analog that stimulates the body to release growth hormone, primarily used to reduce excess abdominal fat (visceral lipodystrophy) in HIV-infected adults, available as a daily subcutaneous injection. It works by mimicking natural GHRH to decrease fat, helping with body composition, and is generally well-tolerated but can cause side effects like joint pain, high blood sugar, or injection site reactions.
What it is and how it works
- Synthetic Hormone: A man-made version of growth hormone-releasing hormone (GHRH).
- Mechanism: Stimulates the pituitary gland to release more growth hormone, which helps decrease fat, especially in the abdomen.
Uses
- Primary Use: Reduces excess stomach fat (visceral adiposity) in adults with HIV-associated lipodystrophy.
- Not for General Weight Loss: Specifically targets fat redistribution, not overall weight loss.
Administration & Dosage
- Form: Subcutaneous (under the skin) injection, typically once daily.
- Injection Site: The abdomen, rotating sites to avoid irritation.
- Preparation: Reconstituted with a provided diluent.
Common Side Effects
- Pain, redness, or swelling at the injection site.
- Joint pain or stiffness.
- Muscle pain or cramps.
- Numbness or tingling in hands/feet (carpal tunnel symptoms).
Serious Side Effects (Report to Doctor)
- Signs of allergic reaction (hives, difficulty breathing, swelling).
- Symptoms of high blood sugar (increased thirst, urination, fatigue, fruity breath).
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