PT-141, also known as bremelanotide, is a synthetic peptide that acts on the central nervous system (brain) to enhance sexual arousal and desire in both men and women, unlike other treatments that focus on blood flow, by activating melanocortin receptors; it’s FDA-approved as Vyleesi for hypoactive sexual desire disorder (HSDD) in premenopausal women, but also used off-label for male sexual dysfunction, though it carries risks like nausea, blood pressure spikes, and potential desensitization with long-term use.
How it Works
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Targets the Brain:PT-141 stimulates melanocortin receptors (MC3R, MC4R) in the brain, which are crucial for sexual function, increasing desire and arousal.
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Neurological Pathway:It activates the nervous system, creating a natural response to sexual stimulation, rather than relying on vascular effects like Viagra.
Uses
- FDA-Approved (Women): Treats HSDD in premenopausal women, not caused by medical/relationship issues or drugs.
- Off-Label (Men): Used to improve libido, arousal, and erectile function.
Administration & Side Effects
- Delivery: Typically given as a subcutaneous injection or nasal spray.
- Common Side Effects: Nausea, flushing, headache, injection site reactions, and potential blood pressure increases.
- Concerns: Risk of blood pressure spikes, especially in those with heart conditions, and potential desensitization with prolonged use.
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