IGF-1 LR3 (Long Arginine 3-Insulin-like Growth Factor 1) is a synthetic protein, a modified version of natural IGF-1, engineered for increased potency and a longer lifespan in the body, making it more effective for cell growth and muscle building in research and potentially for therapeutic use, though it has a strong association with banned substances in sports and research use. Its key modifications include an arginine substitution and an N-terminal peptide extension, which prevent it from binding strongly to IGF-binding proteins, giving it a longer half-life (around 20-30 hours) than natural IGF-1, and it directly promotes muscle growth and tissue repair by boosting protein synthesis.
Key Characteristics & Function
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Structure:An 83-amino acid protein, an altered form of human IGF-1, with higher biological activity.
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Mechanism:Binds to IGF-1 receptors on muscle and bone cells, activating satellite cells for growth, unlike growth hormone (HGH) which primarily acts on the liver.
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Benefits:Promotes nitrogen retention and protein synthesis, aiding muscle mass gain and tissue repair.
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Half-Life:Significantly longer than natural IGF-1, around 20-30 hours.
Applications & Concerns
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Research:Used in stem cell culture and manufacturing for consistent cell maintenance.
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Athletic Use:Popular in bodybuilding for muscle building but is banned by many sports organizations.
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Potential Side Effects:Associated with headaches, swelling, and potential increased cancer risk, according to diet/disease resources.
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