Epitalon (or Epithalon) is a synthetic tetrapeptide (Ala-Glu-Asp-Gly) developed as a bioregulator and anti-aging compound, acting primarily by activating telomerase to lengthen telomeres, the protective ends of chromosomes that shorten with age, potentially slowing cellular aging and promoting regeneration. Research shows it regulates melatonin, enhances mitochondrial function, protects DNA, and balances circadian rhythms, with studies in animals and some human cells indicating lifespan extension, improved vision in retinal disease, and anti-aging effects, though it’s a research peptide with limited clinical application.
Key Functions & Mechanisms:
- Telomere Extension: Stimulates telomerase, an enzyme that adds DNA to telomeres, preventing them from shortening and extending cell life.
- Melatonin Regulation: Influences the pineal gland to increase melatonin synthesis, improving sleep and potentially reducing age-related disorders.
- Antioxidant & Neuroprotective: Protects cells and DNA from oxidative stress, potentially benefiting conditions like Retinitis Pigmentosa by preserving retinal integrity.
- Circadian Rhythm Regulation: Helps stabilize the body’s natural sleep-wake cycle.
Research & Effects:
- Cellular Level: Extends the proliferative lifespan of human fibroblasts and protects oocytes from aging.
- Organisms: Increases lifespan in mice and fruit flies; restores circadian rhythms in monkeys.
- Clinical Potential: Studied for age-related conditions, vision improvement in Retinitis Pigmentosa, and overall vitality.
Administration & Availability:
- Often available as a research chemical or dietary supplement in oral spray or injectable forms.
- Requires consultation with a healthcare professional before use.
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