DSIP most commonly refers to Delta Sleep-Inducing Peptide, a naturally occurring neuropeptide that promotes slow-wave sleep and influences stress, pain, and hormone regulation, first isolated from rabbit brains. It’s studied for treating insomnia and withdrawal, though research continues, and it’s also used in the DOD’s Defense SBIR/STTR Innovation Portal for small business funding applications, and as dSIPRouter, a platform for SIP telecom services.
Delta Sleep-Inducing Peptide (DSIP)
- Function: Promotes deep, restorative sleep (slow-wave sleep) and has effects on pain perception, thermoregulation, and blood pressure.
- Origin: A nonapeptide synthesized in the hypothalamus, found in the brain and plasma, and even in breast milk.
- Uses: Investigated for insomnia, chronic pain, and alcohol/opioid withdrawal, showing promise in animal and some human studies.
- Characteristics: Can cross the blood-brain barrier and modulates sleep naturally without typical sedative dependency, notes Phoenix Pharmaceuticals, Inc..
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