SNAP-8 (Acetyl Octapeptide-3) isn’t a traditional medicine but a powerful anti-wrinkle peptide used topically in high-end skincare, mimicking Botox’s effect by relaxing facial muscles to reduce expression lines (like crow’s feet, forehead lines) without paralysis, working by disrupting the SNARE complex for neurotransmitter release, making it a safer, milder alternative for cosmetics.
What it is:
- A synthetic octapeptide (8 amino acids) derived from SNAP-25 protein.
- An extension of Argireline (Acetyl Hexapeptide-3) with enhanced efficacy.
How it works (Mechanism of Action):
- It interferes with the formation of the SNARE complex, a protein cluster needed for nerve signals to trigger muscle contractions.
- By disrupting this complex, it reduces neurotransmitter release, leading to muscle relaxation and softened wrinkles, similar to Botox but topically and less intensely.
Uses in “Medicines” (Cosmeceuticals):
- Anti-aging: Reduces depth of wrinkles from facial expressions.
- Topical Application: Found in serums, creams, lotions for forehead, eyes (crow’s feet), and lip areas.
- Cosmetic Alternative: A non-invasive, reversible option to injectable neurotoxins.
Important Note:
- SNAP-8 is for topical cosmetic use only, not for injection or internal consumption, and is sold for research/cosmetic formulation, not as a human medicine.





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