5-Amino-1MQ (5-Amino-1-methylquinolinium) is a small molecule used off-label for metabolic support, acting as an inhibitor of the enzyme NNMT, which boosts NAD+ levels, increases metabolism, promotes fat burning, preserves muscle, and supports cellular energy, often used for weight management, body recomposition, and anti-aging by increasing cellular efficiency and potentially activating longevity genes like SIRT1, with animal studies showing promise but human data still emerging.

How it works

- Inhibits NNMT: It blocks the Nicotinamide N-methyltransferase (NNMT) enzyme, which slows metabolism and increases fat storage.
- Increases NAD+: By inhibiting NNMT, it raises cellular NAD+ (Nicotinamide Adenine Dinucleotide) levels, a vital coenzyme for energy production.

Boosts Metabolism: Higher NAD+ promotes a faster metabolic rate and increased fat burning (oxidation).

Activates Sirtuins: It can activate SIRT1 (sirtuin-1), known as the “longevity gene,” linked to various metabolic and age-related conditions.

Potential benefits

Accelerated fat burning and weight loss.
Improved insulin sensitivity and glucose regulation.
Enhanced lean muscle mass and energy.
Anti-aging effects, supporting cellular repair and mitochondrial function.
Improved skin elasticity and reduced inflammation

Usage

Form: Typically available as oral capsules, making it easily accessible.
Dosing: Often started at 50-100mg daily, adjusted by a healthcare provider, used in cycles.
Context: Popular in functional medicine for weight loss and metabolic optimization, sometimes combined with NAD+ therapy.