Survodutide (BI 456906) is an investigational, once-weekly injectable drug, a dual agonist for glucagon and GLP-1 receptors, developed by Boehringer Ingelheim for treating obesity, overweight, and Metabolic Dysfunction-Associated Steatohepatitis (MASH, formerly fatty liver disease), showing promise in weight loss, liver fat reduction, glycemic control, and cardiovascular risk factors. It’s currently in Phase 3 trials (SYNCHRONIZE, LIVERAGE) and has received U.S. FDA Breakthrough Therapy designation for MASH, with potential approval in 2027 if trials succeed. Â
How it works
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Dual Action:ÂActivates both GLP-1 and glucagon receptors, which regulate metabolism, appetite, and energy use.Â
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Metabolic Benefits:ÂIncreases energy expenditure, decreases food intake, improves liver health (reducing fat and fibrosis), and helps control blood sugar.Â
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Unique Design:ÂIt’s designed with a strong bias for GLP-1 receptor activation for weight loss but also leverages glucagon’s direct effects on the liver.Â
Key indications
- Obesity & Overweight: Proven effective for significant weight reduction.Â
- MASH:Â Shows promise in reducing liver fat and fibrosis, even in patients with cirrhosis, a serious form of fatty liver disease.Â
- Cardiovascular Health:Â Demonstrates reductions in blood pressure and triglycerides.Â
Development status
- Phase 3 Trials:Â Underway globally for obesity (SYNCHRONIZE studies) and MASH (LIVERAGE studies).Â
- FDA Designations:Â Holds Breakthrough Therapy designation for MASH.Â
- Availability:Â Not yet on the market;Â expected around 2027 if trials are successful, with results anticipated in early 2026.Â
Reviews
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